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pentobarbital will improve the amount or outcome of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of ivosidenib with sturdy CYP3A4 inducers lowered ivosidenib plasma concentrations.pentobarbital will reduce the extent or effect of cevimeline by influencing hepatic/intestinal enzym